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Mescaline,β-3,4,5-trimethoxy phenethylamin, is a psycho-active hallucinogen alkalloid extracted from cactus of peyote that resemble natural neurotransmitters epinephrine and dopamine. Peyote is a long-time expanding herb in the desert sand area along Texas and Mexico region and continues to be used hundreds of years by Residents of Mexico and South-western America for rituals. Following the civil war in Syria, large number of refugees from Syria where is the neighboring country immigrated to southern cities of Turkey. These people have intense interactions with young individuals living in Turkey, particularly for novelty seeking drug-addicted teens. [Anadolu Psikiyatri Derg 2016; 17(0.300): 68-70]