Objective: This study aims to demonstrate the reliability and validity of Turkish version of DSM-5 Depression Scale which was developed to measure the severity of depression. Methods: The study group included 50 in- or out-patients who met the criteria for major depressive disorder according to DSM-5. Sixty-three healthy volunteers without any mental or physical disease were also recruited as a control group. Beck Depression Inventory (BDI), which is the most widely used self-report scale, was used for concurrent validity. Internal consistency coefficient Cronbach alfa and item-total correlation analysis were performed for reliability. Exploratory factor analysis was used for vali-dity, as BDI was used for concurrent validity. Results: Mean age was 39.2±11.3 and 22.4±5.8 years in the patient and control group, respectively. Sixty-one percent of the sample group (n=66) were female. 64.8% of the group were college graduates, 19% were primary school graduates and 18.5% were high school graduates. Disease dura-tion for major depressive disorder was 3.3±5.6 years for the patient group. For the internal consistency Cronbach alfa coefficient of the DSM-5 Depression Scale was 0.91. Item-total correlation coefficients were between 0.60-0.83. For the exploratory factor analysis of sample adequacy of DSM-5 Depression Scale, Kaiser-Meier-Olkin (KMO) coefficient and Bartlett coefficient was calculated as 0.91 and 608.18, respectively. Single-factor solution was obtained with an eigenvalue of 5.44, representing 60.4% of the variance. Factor loadings of the items were between 0.66-0.80. Correlation coefficient of DSM-5 Depression Scale with BDI was found as r=0.88. Conclusion: The Turkish version of DSM-5 Depression Scale is reliable and valid. [Anadolu Psikiyatri Derg 2017; 18(0.200): 51-56]