Objective: The aim of this study was to determine the relationship between the internalized stigma (IS), addiction characteristics and perceived social support (PSS) characteristics of female inpatient or outpatients undergoing treatment for alcohol and substance use disorder. Methods: This was a cross-sectional, multi-center study. One hundred and five female patients were included according to the criteria of the DSM-5 alcohol or substance use disorder which treated in Istanbul Green Crescents Consultancy Center and four Addiction Centers in Turkey. In this study, an introductory information form, Internalized Stigma in Mental Disorders (ISMI) Scale, Addiction Profile Index (API), Addiction Profile Index-Clinic (API-C) form and Multidimensional Perceived Social Support Scale Re-vised Form (MSPSS) were used. In the evaluation of the data, the number and percentage distributions were made, and the relationship between the variables was examined by analysis of variance and correlation analysis. Results: The mean age of the participants was 30.76. The proportion of currently married was 16.2%, others were single or divorced. 64.7% of the participants stated that they did not work. The economic situation of 78.1% was moderate and low. The relationship between the subscale scores of the ISMI and the MSPSS and API scales were examined. There was a linear relationship showed between alienation, stereotype endorsement and social withdrawal sub-scales of the ISSMD and many features of the API and also depression and anxiety subscales of the API-C. Except for the stigma resistance subscale, a significant positive correlation was found between all subscales of ISMI and MSPSS subscales. Discussion: It is an enormous problem both in Turkey and in the world, stigma has a negative impact on women with addiction was discussed in this study. [Anadolu Psikiyatri Derg 2019; 20(4.000): 377-384]