Duloxetine, a serotonin and norepinephrine reuptake inhibitor, is succesfully used for major depressive disorder, generalized anxiety disorder, stress incontinence, diabetic neuropatic pain and fibromyalgia treatment. Most common side effects of duloxetine are nausea, dry mouth, constipation, sleep disorder, dizziness, fatigue, somnolence, tremor. In short time studies of duloxetine suggest that sexual dysfunction occur with duloxetine less than SSRI. Although sexual side effects such as low ibido, orgasm disorder, ejaculation disorder are common side effects of antidepressant drugs, sponton ejaculation is a side effects that occurs rarely. On the other hand both psychiatric disorders and drugs which used psychiatric disorders affect defecation frequency and form in addition it can cause that patients can have some problems in own daily life. In this paper, case of duloxetine-induced ejaculation with defacation is discussed. [Anadolu Psikiyatri Derg 2017; 18(4.000): 404-406]