A comparative study of the oxidative stress indices of children with autism and healthy children

Cagatay Ugur ¹ , Huseyin Tunca ² , Ebru Sekmen ³ , Ozden Sukran Uneri ³ , Murat Alisik ⁴ , Ozcan Erel ⁴ , Esra Solmaz ⁵

Author Affiliation(s)

Child and Adolescent Psychiatry Department, University of Health Sciences, Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital, Ankara

Child and Adolescent Psychiatry Department, Diyarbakir Child Health and Diseases Hospital, Diyarbakir

Child and Adolescent Psychiatry Department, University of Health Sciences, Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital, Ankara

Biochemistry Department, University of Health Sciences, Ankara Yildirim Beyazit University, Ataturk Training and Research Hospital, Ankara

Child and Adolescent Psychiatry Department, Ankara University Medical School, Ankara

Alpha Psychiatry 2018; 19: 314-322

DOI: 10.5455/apd.276094

Keywords : Autism, oxidative stress, antioxidants, thiol-disulphide, TAS, TOS, OSI, child

Read: 1277 Downloads: 625 Published: 01 June 2018

Volume 19, Issue 3, June 2018

Objective: This study was aimed to analyze the serum total antioxidant/total oxidant (TAS/TOS) levels and thiol/ disulphide balance of children with autism spectrum disorders (ASD) and draws a comparison with those of healthy children. Methods: The study involved 46 children diagnosed with ASD, along with 45 healthy children. The developmental stage, degree of intelligence and autism symptom severity of the ASD group were assessed using the Autism Behavior Checklist (ABC), Problematic Behavior Control List (PBCL), Childhood Autism Checklist Scale (CARS) and developmentally appropriate screening or IQ tests. Clinical, sociological and demographic data were obtained for both groups. The TAS/TOS levels and thiol/disulphide balance of both groups were analyzed and their oxidative stress index was obtained from the formula TAS/TOSx100. SPSS 17.0 was used for statistical analyses. p [Anadolu Psikiyatri Derg 2018; 19(3.000): 314-322]

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