Objective: The aim of this study is to investigate the relationship between depression, anxiety symptoms, economic status and the quality of life of Syrians who applied to the adult refugee mental health outpatient clinic in Istanbul, Turkey. Methods: Syrians who applied to the refugee mental health outpatient clinic for the first time were included in the study. A sociodemographic data form, the Quality of Life Scale (WHOQOL-BREF) and the Hopkins Symptom Checklist (HSCL-25) were administered to the participants. Results: This study found a negative, moderate and significant correlation between both the HSCL-25 depression subscale scores and WHOQOL-BREF scores (r=-0.56, p [Anadolu Psikiyatri Derg 2020; 21(4.000): 403-408]