Sexual dysfunctions such as diminished libido, erectile dysfunction, arousal problems, or delayed orgasm are common side effects of antidepressant medication. However, spontaneous ejaculation is a rare side effect caused by antidepressants. Several case of spontaneous ejaculation have been reported about escitalopram, venlafaxine and reboxetine in the literature. In this paper, a 46-year-old man who developed spontaneous ejaculation with duloxetine is discussed. [Anadolu Psikiyatri Derg 2016; 17(0.300): 14-16]