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Objective: The aim of this study is to adapt KIDSCREEN Health Related Quality of Life (HRQoL) questionnaire into Turkish and to analyze the psychometric properties of the scale. Methods: The study conducted in the city of Manisa located in western Turkey is a validity and reliability study and consisted of 662 children and adolescents between the ages of 8 and 18 and 552 parents. In the study, socio-demographic characteristics of the participants were identified, and KIDSCREEN-52 and KINDL QoL questionnaires were administered. The KIDSCREEN scale was adapted to Turkish and applied psychometric analyses. Results: Cronbach's alpha ranged between 0.69 and 0.95 for the child and adolescent version of the KIDSCREEN-52, KIDSCREEN-27 and KIDSCREEN-10 index and between 0.68 and 0.94 for the proxy version. The results of confirmatory factor analyses fit indices for KIDSCREEN were considered to be at a good level. Correlation coefficient between the dimensions of the KIDSCREEN and KINDL scales assessing similar constructs (ranging between 0.45 and 0.62) were higher than that of other dimensions. In addition, the KIDSCREEN yielded results to discriminate the physical well-being, psychological well-being and perception of insufficient income. Conclusion: Turkish version of the child/adolescent and proxy versions of KIDSCREEN is a valid and reliable measurement tool. [Anadolu Psikiyatri Derg 2016; 17(6.000): 496-505]