Objective: The aim of this study is to demonstrate the reliability and validity of the Turkish Form of DSM-5 Self-Rated Level 1 Cross-Cutting Symptom Scale Adult Version which is developed according to DSM-5 criteria to measure the severity of general symptomatology. Methods: This research was carried out with patients and their relatives who fulfilled the criteria of any psychiatric disorder according to DSM-5 criteria in inpatient and outpatient psychiatric clinics of Manisa Celal Bayar University, School of Medicine and healthy control group without any mental or physical disease. Accordingly, the distribution of psychiatric diagnosis of the patients were as follows: 39 patients with major depressive disorder, three patients with panic disorder, two patients with obsessive-compulsive disorder, four patients with schizophrenia, two patients with schizoaffective disorder, seven patients with BTA anxi-ety disorder, two patients with conversion disorder and post-traumatic stress disorder in one patient. Beside Level 1 Cross-Cutting Symptom Scale, the most widely used for general semptomatology self-rated scale, Symptom Check List-90-Revised Form (SCL-90-R) was used for concurrent validity. In reliability analysis internal consistency coefficient and item-total correlation analysis; in validity analyses exploratory factor analysis and correlation analysis with the SCL-90-R and subscales was performed for validation. Results: This research was carried out with 206 volunteers. 61.2% of the sample group (n=126) were female and the mean age of the study group was 35.1±11.2 years. 29.6% of the group were college graduates, 36.4% primary school graduates, 7.8% middle school graduates and 23.3% were also high school. The internal consistency of the Level 1 Cross-Cutting Symptom Scale was 0.94 and, item-total score correlation coefficients of the Level 1 Cross-Cutting Symptom Scale were between 0.30-0.79. In the exploratory factor analysis, for sample adequacy Kaiser-Meier-Olkin (KMO) coefficient was calculated as 0.92 and Bartlett coefficient was 3007.76. Three-factor solution was obtained, representing 60.8% of the total variance. In the analysis of the correlation between the subscales of SCL-90-R and subscales of the Level 1 Cross-Cutting Symptom Scale were as follows; for depression r=0.72, for anxiety r=0.80, for somatization r=0.72, for psychosis r=0.70, for obsessive compulsive symptoms r=0.68, for personality r=0.72, for suicide r=0.53, for sleep r=0.76, for anger r=0.64 and for the total score r=0.87 was obtained. Conclusion: These findings show that the Level 1 Cross-Cutting Symptom Scale is reliable and valid for Turkish. [Anadolu Psikiyatri Derg 2017; 18(0.200): 5-12]