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Objective: The aim of the present study was to investigate the reliability and validity of Turkish Form of DSM-5 Anxious Distress Specifier Interview for major depressive disorder. Methods: The study was conducted in Psychi-atry Clinic of Yozgat City Hospital. The participants were 40 outpatients met the diagnosis of major depressive disor-der and 72 healthy controls. All participants were evaluated with The Structured Clinical Interview for DSM-5 Disor-ders-Clininican Version (SCID-5-CV), Anxious Distress Rating Scale (ADRS), Hamilton Depression Rating Scale 17 item form (HAMD-17) and Hamilton Anxiety Rating Scale (HAMA). Internal consistency coefficient was calcu-lated and item-total score correlation analysis was made for evaluating reliability. Exploratory factor analysis for factor validity and Pearsons correlation and partial correlation analyses for discriminant-convergent validity were conducted. Mann-Whitney U test and ROC analysis were performed so as to show how much ADRS differentiates the patient group and the control group. Results: As a result of the validity analysis, it was observed that the single-factor design of the scale was confirmed, item factor loads were between 0.664-0.817, and discriminant-convergent validity was provided. Internal consistency coefficient was 0.764, and the item-total score correlation coefficients ranged from 0.540 to 0.655. In ROC analysis area under the curve was 0.98. ADRS total score of the patients was found to be significantly higher than the controls (p [Anadolu Psikiyatri Derg 2020; 21(0.200): 21-28]