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Edema can be observed as a symptom of a wide variety of diseases. The atypical antipsychotic olanzapine is rarely related with peripheral edema. The relationship between olanzapine and edema is still unclear. In this case report, a periorbital edema developing shortly after initiation of olanzapine treatment in a patient with schizophrenia is reported and the possible causes for edema are discussed. [Anadolu Psikiyatri Derg 2017; 18(0.100): 56-58]