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Selective serotonin reuptake inhibitors are generally first choice drugs in the treatment of depression, anxiety disorder, eating disorder and various psychiatric disturbances, such as impulse control disorder. Sertraline is a selective serotonin reuptake inhibitor. It also makes dopamine reuptake inhibition. It may show somnolence, nervousness, sweating, drowsiness, insomnia, dizziness, nausea, chilling, skin rash, dyspepsia, loss of appetite, headache, diarrhea, ejaculation disorder, dry mouth, and weight loss as side effects. It has been reported that akathisia, dystonia, tardive dyskinesia and Parkinsonism may be seen as the extrapyramidal system findings during use of sertraline. Acute dystonia is a psychiatric emergency. It develops not only due to use of antipsychotics but, it has also been reported to occur due to use of antiemetics and antidepressants as well. In this report, we present a case with oromandibular dystonia, which developed during 50 mg sertraline treatment on the patient with adjustment disorder. Clinicians should always keep in their mind that there may be extrapyramidal side effects during use of selective serotonin reuptake inhibitors. [Anadolu Psikiyatri Derg 2017; 18(0.100): 59-61]