Olfactory reference syndrome (ORS ) is a delusional disorder of somatic type of characterized by persistent wrong belief that the person has bad odor originating from his/her body . Patients with ORS feel responsible for themselves for the bad odor and shame. Patients often withdraw from the society, they restrict their social and occupational communication. In this report we present a case with a delusion related to bad odor of his body and secondary depressive symptoms who presented significant improvement with the combination of escitalopram and olanzapine. [Anadolu Psikiyatri Derg 2016; 17(0.300): 31-34]