Invited Review

Neuropsychiatric Consequences of COVID-19 Pandemic: A Synthetic Review from a Global Perspective


Somnogen Canada Inc., College Street, Toronto, Canada


Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India


Sleep research unit, Department of Psychiatry, Faculty of Medicine, Mansoura University, Egypt


Department of Psychiatry, North Area Armed Forces Hospital (NAAFH) KSA, Saudi Arabia


Department of Rehabilitation Medicine, North Area -Armed Forces Hospital (NAAFH)-KSA, Saudi Arabia


Department of Chest Medicine, Faculty of Medicine, Mansoura University, Egypt


Department of Nursing, College of Applied Medical Sciences, Majmaah University, Majmaah, Saudi Arabia


University Sleep Disorders Center, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia


Strategic Technologies Program of the National Plan for Sciences and Technology and Innovation in the Kingdom of Saudi Arabia


College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Kingdom of Bahrain


Ministry of Health, Manama, Kingdom of Bahrain


Division of Community Psychiatry, M. S. Chellamuthu Trust and Research Foundation, Madurai, India


Independent Researcher, Narayanapuram, Madurai, Tamil Nadu, India


Department of Psychiatry, Chulalongkorn University Faculty of Medicine, Bangkok, Thailand


Department of Psychiatry, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada


Department of Medicine, Columbia University, New York, NY, USA


Department of Psychiatry, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India


Department of Neuropsychiatry and Behavioral Science, Columbia, University of South Carolina, South Carolina, USA


Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland


Department of Cell Systems and Anatomy, UT Health San Antonio, San Antonio, Texas USA


The Institute for Mental and Physical Health and Clinical Translation Strategy Research Centre, Deakin University School of Medicine, Geelong Victoria, Australia


School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia


Department of Psychiatry, University of Melbourne, Parkville, Australia


Orygen Youth Health Research Centre, Parkville, Australia


Department of Psychiatry, University of Toronto, Canada


SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, South Africa


Neuroscience Education Institute, University of California San Diego, San Diego, CA, USA


Departments of Psychiatry, Neuroscience, and Pharmacological Sciences, Mount Sinai School of Medicine, New York, NY, USA

Alpha Psychiatry 2022; 23: 144-154
DOI: 10.5152/alphapsychiatry.2022.21783
Read: 2990 Downloads: 542 Published: 17 February 2022

Some research suggests that distress, secondary to isolation and fear following COVID-19 infection, can negatively affect the long-term more than the COVID-19 infec- tion itself. This narrative review aims to provide a global view on the neuropsychiatric con- sequences of COVID-19 that can be ascribed to several factors, ranging from the direct effect of infection, to the body’s responses against the infection, or to the psychologi- cal sequelae of social isolation, unemployment, and fear for one’s health and livelihood. Current findings show that the more severe the respiratory infection, the more likely are central nervous system (CNS) complications regarding the infection itself. The immune reactions to the infection may result in symptoms similar to chronic fatigue as well as neurocognitive deficits, which last long after the infection is gone. An increase in symp- toms of depression, anxiety, and trauma-related stress may also follow upon economic fears and isolation from friends and family. The consequences of the pandemic are not limited to adults; children learning remotely and away from classmates and routine activi- ties may develop adjustment disorders, acute stress disorder, and a variety of manifesta- tions of grief. A summary of case reports suggests that COVID-19-related stress, economic recession, and political unrest increase the risk of suicidal behaviors and acts of violence. However, it is unknown whether manifestations of mental disorders result from social causes or whether CNS complications may be responsible.

Cite this article as: Pandi-Perumal SR, Zaki NF, Qasim M, et al. Neuropsychiatric consequences of COVID-19 pandemic: A synthetic review from a global perspective. Alpha Psychiatry. 2022;23(4):144-154.

EISSN 2757-8038