Objective: In this study, it was investigated whether there was a difference in terms of internalized stigmatization and perceived social support between alcohol use disorder (AUD) and opioid use disorder (OUD). Methods: At least primary school graduates who were followed up inpatient and gave voluntary consent to participate in the study were included in the study. Descriptive information form, The Internalized Stigma of Mental Illness Scale and Multidimensional Perceived Social Support Scale were administered. Statistical analysis was performed with SPSS 23 program. Results: Family perceived (p=0.005) and total perceived social support (p=0.027) were higher in pa-tients with OUD. The Stereotypes (p=0.010), social withdrawal (p=0.035), stigmatization resistance (p=0.022) and total stigmatization (p=0.021) scores were higher in patients with AUD. Discussion: Negative perception of belief and cultural alcohol use in our country may be effective in having higher ISMI score and lower MPSS score in pa-tients with AUD. [Anadolu Psikiyatri Derg 2019; 20(0.200): 51-54]