Objective: The aim of the study is to examine the life-long relationship between premenstrual syndrome (PMS) symptoms and mania/hypomania symptoms and declared personality structure among girls who are university students. Methods: A total of 294 volunteers selected by random sampling method from 13 universities located in Fatih (4), Sisli (5) and Uskudar (4) districts of Istanbul were included in the study. The inventories used in data collection phase of the study are Premenstrual Assessment Form (PAF), the Mood Disorder Questionnaire (MDQ) and a Sociodemographic Form developed by the research group. Results: %5.1 of the participants (n=15) are between 17-19 years of age, %83.7 (n=246) are between 20-23 years of age, %5.1 (n=15) are 24-26 years of age and % 6.1 (n=18) are 27-28 years of age. There is a significant correlation between depressive affect, anxiety, fatigue, irritability, depressive thoughts, pain, appetite changes and sleep thoughts which are the dimensions of PAF and MDQ scores. There is a significant relationship between the age variable and depressive affect, depressive thoughts and MDQ scores. There is a significant relationship between depressive affect, anxiety, fatigue, irritability, depressive thoughts, pain, appetite changes and sleep thoughts which are the dimensions of Premenstrual Assessment Form and declared personality structure. Conclusion: According to the findings of our study, there is a statistically significant relationship between hormonal changes in PMS and mania/hypomania symptoms. Additionally, there is a statistically significant relationship between PMS and declared personality structure. [Anadolu Psikiyatri Derg 2017; 18(6.000): 551-560]