Zuclopenthixol decanoate depot is an effective and safe antipsychotic which is treatment choice particularly in non-compliant patients with schizophrenia. In this article, a case developing hypertensive crisis after zuclopenthixol decanoate depot is reported first time in the literature. As in other antipsychotics, risk of life threatening adverse effects does exist also after zuclopenthixol decanoate injection and since elimination of depot antipsychotics from the body may take weeks or months, clinicians should be aware of risk imposed by starting therapy directly by a depot antipsychotic. [Anadolu Psikiyatri Derg 2017; 18(0.100): 62-64]