Trazodone was the first second-generation antidepressant; it is a weak inhibitor of serotonin reuptake but a strong antagonist of serotonin type 2A (5HT2A) and type 2C (5HT2C) receptors. Galactorrhea associated with antidepressant use has rarely been reported in the literature. To our knowledge, this is the second case report of galactorrhea associated with trazodone use so far. Here, we report the case of a patient treated with duloxetine and quetiapine for 5 months; however, quetiapine was discontinued because of dizziness and drowsiness. Quetiapine was replaced with trazadone; however, we observed that the patient developed galactorrhea within 4 weeks of treatment initiation. [Anadolu Psikiyatri Derg 2019; 20(3.000): 333-335]