Objective: Number of studies evaluating oxidative stress in unipolar depression are increasing. The aim of this study was to evaluate the scores of oxidative stress in unipolar depression patients and in mixed type of unipolar depression and to compare these scores with healthy subjects in terms of dynamic thiol/disulfide balance para-meters. Methods: Ninety-eight patients aged between 18 and 65 years with the diagnosis of unipolar depressive disorder diagnosed according to DSM-5 criteria and 97 age- and sex-matched 97 healthy individuals who applied to the Psychiatry Outpatient Clinic of Canakkale Onsekiz Mart University Faculty of Medicine Psychiatry Department between April 2018 and September 2018 were included in the study. Hamilton Depression Rating Scale (HAM-Dand Modified Hypomania Checklist (M-HCL) were used respectively to determine depressive symptoms, manic symptoms and the severity of the disease. Oxidative stress parameters were measured by evaluating fasting blood samples taken from all participants. Results: In the unipolar depression group, the levels of disulfide, total thiol, oxidation-reduction and oxidized thiol levels were found to be statistically significant in favor of oxidation (p [Anadolu Psikiyatri Derg 2020; 21(4.000): 341-348]