Original Article

Evaluation of Arterial Stiffness in Depression Patients


Department of Psychiatry, Elazığ Fethi Sekin City Hospital, Elazığ, Turkey


Department of Psychiatry, University of Binali Yıldırım, Erzincan, Turkey


Department of Psychiatry, University of Bozok, Yozgat, Turkey


Department of Public Health, Adıyaman Provincial Health Directorate, Adıyaman, Turkey


Department of Psychiatry, University of Fırat, Elazığ, Turkey


Department of Psichiatry, Firat University School of Medicine, Elazig, Turkey

Alpha Psychiatry 2023; 24: 193-199
DOI: 10.5152/alphapsychiatry.2023.221099
Read: 559 Downloads: 326 Published: 16 October 2023

Background: It has been known that there is a significant correlation between depression and cardiovascular diseases. However, the reasons behind this correlation that could affect mortality and morbidity were not fully identified. The present study aimed to analyze arterial stiffness diagnosed with ultrasonography, which could be associated with cardiovascular disease risks in depression patients, and to compare the findings with those of healthy controls.

Methods: The study was conducted with 35 depression patients and 35 healthy individuals. Routine complete blood and biochemistry tests were requested for all patients, and their weight and height, waist circumference, and diastolic and systolic arterial blood pressure were measured. Femoral and carotid artery intima-media thickness and other arterial stiffness parameters were determined with Doppler ultrasonography.

Results: It was determined that the systolic pressure (P=.028) was higher in the patient group (P=.028). Also, the carotid elastic modulus (P=.048) was significantly higher in the patient group. A negative and significant correlation was determined between femoral compliance and chlorpromazine equivalent dose (P=.021, r=−0.389).

Conclusion: It was determined that the systolic blood pressure and carotid elastic modulus arterial stiffness parameters were significantly higher in depression patients. Measurable arterial stiffness parameters should be investigated in depression patients as cardiovascular risk markers. Furthermore, the determination of the effects of psychotropic drugs employed in arterial stiffness treatment could play an important role in the determination of cardiovascular disease risk in these patients.

Cite this article as: Sırlıer Emir B, Yıldız S, Kazgan Kılıçaslan A, et al. Evaluation of arterial stiffness in depression patients. Alpha Psychiatry. 2023;24(5):193-199.

EISSN 2757-8038