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Objective: In this study, we investigated whether the relationship between internalized stigmatization, perceived social support and addictive dimensions in inpatients receiving alcohol, cannabinoid or opioid use disorder (AUD, CnUD, OpUD) in an addiction center changes according to the preferred substance. Method: At least primary school graduates who were followed up inpatient and who gave voluntary consent to participate in the study were included in the study. Descriptive information form, Dependency Profile Index (DPI), The Internalized Stigma of Mental Illness Scale (ISMI) and Multidimensional Perceived Social Support Scale (MPSS) were administered. Statistical analysis was performed with SPSS 23 program. Results: There was a negative correlation between MPSS and ISMI and DPI in patients with AUD. There was no correlation between ISMI and DPI in patients with AUD. A positive correlation was found between the ISMI stereotype endorsement subscale and DPI severe desire. subscale in patients with KnKB. In addition, a negative correlation was found between MPSS friend subscale and DPI effect on life subscale. There was no correlation between ISMI and DPI in patients with OpUD, but there was a positive correlation between ISMI stigmatization resistance subscale and DPI motivation to give up substance subscale; there was a negative correlation between MRSS friend subscale and ISMI stereotype endorsement subscale, MPSS special subscale and ISMI perceived discrimination subscale. Discussion: The effect of MPSS on ISMI and DPI was found to be higher in patients with AUD compared to those with both KnUD and OpUD. The results are important in terms of understanding the factors influencing internalized stigmatization and perceived social support, which are important in treatment success, and the need for different intervention methods in patients with different substance use disorders. [Anadolu Psikiyatri Derg 2020; 21(6.000): 609-616]