Depot antipsychotics in the treatment of schizophrenia: Haloperidol decanoate

If patients are partially or totally non-adherent and discontinuation rates remain high even the most effective medications will have little or no impact. There is a range of factors that can affect adherence, including poor patient insight, the level of social and family support, early medication acceptance, past medication experiences and fears about medication. Using depot injectables, simplifying the dosing regimen and dose adjustment are some of the options for pharmacological interventions that may be used to enhance medication adherence in patients with psychosis.