Clozapine is used specifically with treatment resistant schizophrenia and is a highly effective antipsychotic. However some of its side effects which vary in severity limits its usage. Nocturnal enuresis is one of the rarely seen but disturbing side effects of clozapine, and its mechanism is multifaceted. In this paper two cases with enuresis nocturna due to clozapine and their treatments are discussed. It is important to consider and manage this side effect in adjusting the dosage process of clozapine which tends to cause enuresis in higher rates than other atypical antipsychotics. Furthermore it should to be kept in mind that adjusting the dosage of clozapine, and aripiprazol combination treatments may be an alternative treatment as well. [Anadolu Psikiyatri Derg 2016; 17(0.300): 58-60]