Angioedema can be occur a drug adverse reaction. Drugs such as non-steroidal anti-inflammatory drugs (NSAIDs), antihypertensive drugs, antibiotics, proton pump inhibitors, fibrinolytic agents, estrogens, calcium channel blockers, beta blockers, and psychotropic drugs (such as serotonin reuptake inhibitors-SSRIs) can induce this reaction. In the literature, there are few case reports about angioedema induced by SSRIs and there is no case report related to atomoxetine. Herein we report a case of angioedema which occurred after initiation of atomoxetine in a 9-year-old girl being treated for attention deficit and hyperactivity disorder; the side effect disappeared after discontinuation. [Anadolu Psikiyatri Derg 2016; 17(0.300): 35-37]