The development of depot antipsychotics are facilitated incompitable patients treatment process for in terms of chronic disease course. One of the disadvantages of depot antipsychotics, having various advantages and disadvantages, neuroleptic malignant syndrome (NMS) rate is higher than the oral form. NMS, rare but can be fatal, is an idiosyncratic reaction characterized by confusion, hyperthermia, autonomic dysfunction, muscle rigidity after use of neuroleptics. In this case, a schizophrenia patient used to haloperidol depot, named haldol decanoate in abroad used since1986 (Europe-US) but recently introduced in Turkey, with NMS was reported. [Anadolu Psikiyatri Derg 2016; 17(0.300): 11-13]